Increasing evidence shows link between Parkinson’s and gut health
Revolutionary faecal transplants are the latest new treatment option being trialled in people living with Parkinson’s to help manage their debilitating symptoms by replenishing their healthy gut bacteria.
The trial is the result of an exciting collaboration between leading Australian biotechnology company BiomeBank; the Departments of Neurology, Nuclear Medicine and Gastroenterology within The Queen Elizabeth Hospital and Royal Adelaide Hospital; and The Hospital Research Foundation (THRF) Group.
There has been increasing evidence showing the link between Parkinson’s and gut health. Constipation affects 90 per cent of people living with Parkinson’s, and recent research has also indicated the microbiome within the gut may influence the response to existing therapies for the disease.
BiomeBank CEO Thomas Mitchell and Co-Founder Dr Sam Costello
BiomeBank is world-leading for its cutting-edge science, innovative technologies and drug manufacturing capabilities, developing microbial therapies with the potential to offer world-first treatments for a number of diseases.
The company’s first drug product is already being used throughout Australia to treat the debilitating gut condition Clostridioides difficile (C-diff) through faecal microbiota transplantation (FMT).
“Constipation is a common problem for many people with Parkinson’s and has a wider impact on the person’s health and wellbeing,” says Dr Robert Bryant, co-founder and VP of Translational Medicine at BiomeBank and gastroenterologist at The Queen Elizabeth Hospital.
“The aim of this trial is to meet an unmet medical need, exploring whether our microbial therapy is safe and tolerable in people with Parkinson’s disease. The study will also provide some preliminary information on whether FMT might improve motor and non-motor symptoms of Parkinson’s including constipation. Results of this pilot study will inform the design of future larger studies.
“This is an interventional clinical study which is an important first step for microbial drug development, placing Adelaide on the map globally for this innovative patient-driven research and drug discovery.
“In an exciting SA-first, the biological impact of FMT on these patients will also be assessed. The trial is being led by Associate Professor Thomas Kimber, neurologist at the Royal Adelaide Hospital, who is integrating dopamine scans which monitors the brain for abnormalities.”
“I’m hoping this research will change my life.”
Cassandra Hewett lives with Young Onset Parkinson’s and hopes to benefit from the study. She says her chronic constipation is “painful” and “the source of so much discomfort”.
“I’m a person that does all the things that I’m supposed to in order to help such as a special diet, exercise, make sure I drink lots of water – but nothing helps,” she says.
“I’m hoping this research will change my life.”
Leading Adelaide businessman Kevin Weeks is financially backing the trial, through The Hospital Research Foundation Group. Living with Parkinson’s himself and on the Board of THRF Group charity Parkinson’s SA, Kevin knows how living with the daily symptoms of Parkinson’s can affect people’s quality of life.
“Gut health has been linked to so many conditions and it is exciting that a South Australian company might improve our understanding of this connection,” Kevin says.
“I’m funding this trial because I want to back research that produces immediate improvements for people living with Parkinson’s.”
Seeking people living with Parkinson’s to participate in the trial
People living with Parkinson’s are being sought to participate in the trial, where they’ll be provided with a six-month course of FMT from BiomeBank.
If you would like to participate, you must have a confirmed diagnosis of idiopathic Parkinson’s, receiving levodopa therapy and experiencing a fluctuating response to levodopa.
Please contact Dr Michele De Sciscio during business hours via phone 0422 447 902 or email michele.descisc[email protected] for more information and to register your interest.
